Highways said the crash happened on the southbound M6 at junction 31 (Preston, A59) at around 9.15am.
Lanes 3 and 4 have been closed, between junctions J31A and J31, whilst the vehicles await recovery.
The crash is leading to delays of around 10 minutes.
Highways said efforts are being made to re-open the lanes as quickly as possible and it expects the incident to be cleared by 10.45am.
It is not known at this stage whether anyone has been injured in the crash.
North West Ambulance Service have been approached for comment.
