Fences have been erected around the perimeter of the former Mitchells Brewery site in Lancaster.
The large white fencing went up last week around sections of the Canal Corridor North site, which has been earmarked for development by British Land.
One observer said workmen had told him some of the buildings may be getting demolished.
The fences have been erected around a derelict parcel of land in Moor Lane, and in Lodge Street, Edward Street and Brewery Lane.
Jon Davis, landlord at The Golden Lion pub in Moor Lane, said that no-one had been in touch with him about future plans for the site.
He said: “They have boarded up the old Classic Drinks building at the end of Brewery Lane as well.
“I do get the feeling that something is beginning to happen round there.
“But all the conversations regarding the development seam to involve The Grand and The Dukes but no one has been in touch with ourselves or the Music Co-op.”
Staff at Lancaster Musicians Co-op in Lodge Street also say they are frustrated by the lack of communication.
A spokeswoman for British Land said: “Works to repair a collapsed wall in one of the former Mitchell’s storage warehouses is being undertaken to ensure the safety of the building.
“We’re also carrying out some survey work at the same time.
“We’re continuing to consult with both the city and county councils, English Heritage and other key stakeholders on our proposals for the scheme.”