The A6 between J33 of the M6 and Lancaster is the most dangerous road in the country for cyclists and pedestrians.
Figures released by the Road Safety Foundation, which campaigns for safer roads around the country, places the 9km stretch of the A6 at number five in the UK’s persistently higher risk roads.
But the figures also reveal that the A6 has the highest number of fatal and serious crashes.
The accidents were between 2007-09 and 2010-12, with 64 per cent of these involving pedestrians and cyclists. This is higher than any other road on the list.
The A589 - which covers Middleton Way, Heysham Road, Marine Road Central and Broadway - is the eigth most dangerous road in the UK.
On the A6 between 2007-09 - there were 27 fatal and serious crashes, and 25 in 2010-12.
Lancashire County Council, which is responsible for highways in the county, said that speeding motorists was a big factor in many of the incidents.
Paul Binks, road and transport safety manager for Lancashire County Council, said: “We gather data on all incidents resulting in deaths and injuries across Lancashire and analyse the circumstances to identify common causes which allow us to prioritise measures to prevent future incidents.
“These roads do have a record of incidents resulting in deaths and serious injuries with speeding being a factor in many of them.
“We therefore work closely with the police to enforce the speed limits using mobile speed cameras as part of the Lancashire Road Watch programme.
“We also have a programme of safety schemes to improve roads in locations where analysis suggests measures such as engineering or signage may reduce accidents and are investing £1m over the next two years across the county.”
In May, the Lancaster Guardian obtained figures from Lancashire Police which revealed that serious cycling injuries had more than doubled in the city over the last four years.
The Road Safety Foundation, said the majority of British road deaths are concentrated on just 10 per cent of the British road network, motorways and ‘A’ roads outside major urban areas.
Their report measures and maps the differing risk of death and serious injury road users face across this network, sometimes 20 times or more different.
Lancaster also has the second slowest rush hour traffic in the country, according to a recent survey, behind Westminster in Central London.