The M6 is expected to fully reopen shortly after it was closed following a two-vehicle collision.
Lanes two and three of the southbound carriageway are now open after the motorway was shut just after 9am after a collision which saw one vehicle roll on its side between Junction 32 at Preston and Junction 33 at Galgate.
The two drivers, a man and a woman, have been taken to Royal Preston Hospital with one airlifted.
Lancashire Police are asking drivers to “avoid the area where possible”.
Shortly before 10.30am, the northbound carriageway was also closed as the North West Air Ambulance landed at the site.
The Highways Agency said the accident involved four vehicles and it is believed firefighters have cut the roof from one vehicle to remove its occupants.
They expect the southbound carriageway to be closed until 11.45am with traffic taken off the motorway at Junction 33.